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Anti-ATPase MORC2 Rabbit pAb (100 μl)
| Reactivity: | M,R |
| Applications: | IHC/IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | ATPase MORC2 rabbit polyclonal antibody |
Gene Name: | ATPase MORC2A |
Synonyms: | MORC family CW-type zinc finger protein 2A, Zinc finger CW-type coiled-coil domain protein 1, Morc2a, CW-Type With Coiled-Coil Domain 1, Zinc Finger, ATPase MORC2 |
Immunogen: | Recombinantproteincorrespondingto Mouse ATPase MORC2 |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | Nucleus, Cytoplasm |
Uniprot ID: | Q69ZX6 |
Product Usage Information
Applications | Species | Dilution | Positive Sample |
IHC/IF | Mouse, Rat | 1: 500-1: 2000 | brain, testis |
Background
Essential for epigenetic silencing by the HUSH complex. Recruited by HUSH to target site in heterochromatin, the ATPase activity and homodimerization are critical for HUSH-mediated silencing. Represses germ cell-related genes and L1 retrotransposons in collaboration with SETDB1 and the HUSH complex, the silencing is dependent of repressive epigenetic modifications, such as H3K9me3 mark. Silencing events often occur within introns of transcriptionally active genes, and lead to the down-regulation of host gene expression.
Images
| Immunohistochemistry of paraffin embedded mouse testis using ZCWCC1 (GB111662) at dilution of 1:1000 (300x lens) |
| Immunohistochemistry of paraffin embedded rat brain using ZCWCC1 (GB111662) at dilution of 1:1000 (300x lens) |
| Immunofluorescence of paraffin embedded mouse brain using ZCWCC1 (GB111662) at dilution of 1:1000 (400x lens) |
| Immunofluorescence of paraffin embedded mouse testis using ZCWCC1 (GB111662) at dilution of 1:1000 (400x lens) |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
